The United legend was placed in temporary charge following the dismissal of Erik ten Hag on Monday.
With Ruben Amorim not expected to officially take the reins until November’s international break, van Nistelrooy will have three more games as interim manager following Wednesday’s thrilling Carabao Cup win over Leicester City.
The Dutchman is likely to still be without Kobbie Mainoo and Harry Maguire for the visit of Chelsea with the pair still recovering from respective thigh and knee injuries.
Luke Shaw remains unavailable with Ten Hag confirming in his final correspondence as United manager the left-back has suffered yet another injury setback with his recovery ‘not going as we expected’.
Shaw has not played for his club since February and with Tyrell Malacia also still working his way back towards full fitness after his extended lay-off, van Nistelrooy is likely to remain without a recognised left-back option.
United are still to confirm the extent of Antony’s injury after he was stretchered off with what was reported to be an ankle sprain against Fenerbahce last week.
Predicted Man Utd XI to face Chelsea
Onana, Mazraoui, de Ligt, Martinez, Dalot, Ugarte, Casemiro, Rashford, Fernandes, Garnacho, Hojlund
Predicted Chelsea XI to fact Man Utd
Sanchez, Gusto, Fofana, Colwill, James, Caicedo, Lavia, Madueke, Palmer, Neto, Jackson
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