The new-look competition gets under way at Old Trafford on Wednesday evening as Erik ten Hag leads the Red Devils out against the club he made his name with.
United are favourites to beat the side that finished third in last season’s Eredivisie, but Twente boss Oosting feels a result is possible against the Premier League outfit.
“I always believe in opportunities,” he said. “If we dare to play, we can also create opportunities. Especially in the transition, we can hurt Manchester.
“That is easier said than done but the will is definitely there. We played games against Red Bull (Salzburg, in the Champions League qualifying stage) that you learn from.
“Everything goes at the highest tempo, whether it is on the ball or in defence. You have to be top in everything and we need everyone to be there. I think we have also made progress in that.
“We have respect for Manchester United, but we also have the full conviction and the will to get the most out of the game.”
Twente will be cheered on by around 4,000 fans at Old Trafford – the club’s largest ever European away support.
“I think that’s great that so many supporters have come this way to support us here,” Oosting added.
“Outside the hotel we saw supporters walking this afternoon. I think that’s great.”
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